Sheikh Zakaria Mosque is one of Gaza’s historic mosques, located in the city center northwest of the Old City, in Al-Daraj neighborhood on Al-Wehda Street, near the ancient Sheikh Khaled Mosque. It was built in the 14th century AD (mid-8th century AH) during the Mamluk era by order of the Commander of Commanders Al-Sayfi, the governor of the Mamluk kingdom of Gaza. Sheikh Zakaria, after whom the mosque was named, was buried in it following his death in 749 AH. The mosque once had endowments including shops in the Al-Burjaya neighborhood.

Only its minaret remained standing for a time, and among its remnants was a stone slab inscribed with: “This blessed house was constructed, God willing, by order of our lord, the Commander of Commanders… Al-Sayfi, governor of the Mamluk kingdom of Gaza – may God grant him victory – in the month of Muharram, year 410 AH.”

On April 11, 2024, Israeli occupation aircraft targeted Sheikh Zakaria Mosque in Al-Daraj neighborhood in Gaza City, leading to its complete destruction.