Al-Shuhada Mosque in Khan Younis is considered one of the most prominent religious landmarks in the city. It is located in the Khan Younis Al-Balad area in the southern Gaza Strip. The mosque served as a vital center for worship and religious and social gatherings, hosting daily and Friday prayers, as well as religious lessons and lectures.

On 11 December 2023, Israeli occupation aircraft targeted Al-Shuhada Mosque in Khan Younis, southern Gaza Strip, resulting in its complete destruction.